1. JC Monahan NBC10Boston - Facebook
JC Monahan NBC10Boston. 19991 likes · 8 talking about this. Follow me on Twitter: https://twitter.com/JCMonahan.
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2. 'I was convinced no one would ever understand': JC Monahan shared ...
7 apr 2021 · NBC10 Boston's JC Monahan is sharing her struggles with depression and “debilitating” anxiety. Read more on Boston.com.
NBC10 Boston’s JC Monahan is sharing her struggles with depression and “debilitating” anxiety with the hope that opening up about her experiences may help others grappling with mental health issues. In […]
3. Breaking Her Silence: JC's Personal Journey Through Depression and ...
27 sep 2023 · JC Monahan is an Emmy award winning journalist with more than 25 years of experience. She is also an AMS sealed meteorologist. In 2001 JC began ...
See Also7 Best Websites To Buy A Used Car in Netherlands6:30 P.m. EtDream Big! Career, Internship & Graduate School Fair | SUNY OswegoUAF Administration, Faculty and Emeriti · UAF . Administration, Faculty and Emeriti. ... UAF ADMINISTRATION. ... 2000—Professor of Marine Science ... - [PDF Document]Check out the latest community post from one of your neighbors. (The views expressed in this post are the author’s own.)
4. Liquid-Liquid Phase Separation of Histone Proteins in Cells - NCBI
Liquid-liquid phase separation (LLPS) of proteins and nucleic acids has emerged as an important phenomenon in membraneless intracellular organization.
Liquid-liquid phase separation (LLPS) of proteins and nucleic acids has emerged as an important phenomenon in membraneless intracellular organization. We demonstrate that the linker histone H1 condenses into liquid-like droplets in the nuclei of HeLa ...
5. Biomolecular Phase Separation: From Molecular Driving Forces to ... - NCBI
20 apr 2021 · Cross-interaction-driven phase separation is the phase separation ... Monahan Z, Ryan VH, Janke AM, Burke KA ... JC, Li CH, Guo YE, Day DS, ...
See AlsoPerlita TangoBiological phase separation is known to be important for cellular organization, recently extending to a new class of biomolecules that form liquid-like droplets coexisting with the surrounding cellular, or extracellular environment. These droplets are ...
6. The Role of Post-Translational Modifications on Prion-Like ... - MDPI
... Separation of FUS. by. Shannon N. Rhoads. Shannon N. Rhoads. SciProfiles Scilit Preprints.org Google Scholar. ,. Zachary T. Monahan. Zachary T. Monahan.
Subcellular mislocalization and aggregation of the human FUS protein occurs in neurons of patients with subtypes of amyotrophic lateral sclerosis and frontotemporal dementia. FUS is one of several RNA-binding proteins that can functionally self-associate into distinct liquid-phase droplet structures. It is postulated that aberrant interactions within the dense phase-separated state can potentiate FUS’s transition into solid prion-like aggregates that cause disease. FUS is post-translationally modified at numerous positions, which affect both its localization and aggregation propensity. These modifications may influence FUS-linked pathology and serve as therapeutic targets.
7. Smad2/3/4 complex could undergo liquid liquid phase separation and ...
21 mei 2024 · Lai HS, Lee JC, Lee PH, Wang ST, Chen WJ. Plasma free amino acid profile in cancer patients. Semin Cancer Biol. 2005;15(4):267–76. Article CAS ...
Hepatocellular carcinoma (HCC) represents one of the most significant causes of mortality due to cancer-related deaths. It has been previously reported that the TGF-β signaling pathway may be associated with tumor progression. However, the relationship between TGF-β signaling pathway and HCC remains to be further elucidated. The objective of our research was to investigate the impact of TGF-β signaling pathway on HCC progression as well as the potential regulatory mechanism involved. We conducted a series of bioinformatics analyses to screen and filter the most relevant hub genes associated with HCC. E. coli was utilized to express recombinant protein, and the Ni–NTA column was employed for purification of the target protein. Liquid liquid phase separation (LLPS) of protein in vitro, and fluorescent recovery after photobleaching (FRAP) were utilized to verify whether the target proteins had the ability to drive force LLPS. Western blot and quantitative real-time polymerase chain reaction (qPCR) were utilized to assess gene expression levels. Transcription factor binding sites of DNA were identified by chromatin immunoprecipitation (CHIP) qPCR. Flow cytometry was employed to examine cell apoptosis. Knockdown of target genes was achieved through shRNA. Cell Counting Kit-8 (CCK-8), colony formation assays, and nude mice tumor transplantation were utilized to test cell proliferation ability in vitro and in vivo. We found that Smad2/3/4 complex could regulate tyrosine aminotransfe...
8. [PDF] The synergic effect of water and biomolecules in intracellular phase ...
Ferreon, J. C. et al. Acetylation disfavors tau phase separation. Int. J. Mol. Sci. 19, 1360. (2018). 13. Monahan ...
9. Liquid–liquid phase separation in human health and diseases - Nature
2 aug 2021 · Methods to study liquid separation are being developed (to observe LLPS); we review them below. ... Monahan, Z. et al. Phosphorylation of the ...
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases. In this review, we describe our current understanding of LLPS and summarize its physiological functions. We further describe the role of LLPS in the development of human diseases. Additionally, we review the recently developed methods for studying LLPS. Although LLPS research is in its infancy—but is fast-growing—it is clear that LLPS plays an essential role in the development of pathophysiological conditions. This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.
10. Long way up: rethink diseases in light of phase separation and phase ...
Bottom: on the other side, original physiological LLPS partially or totally lose phase separation, termed loss of phase separation (LoPS). ... Monahan et al., ...
Abstract. Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compart
