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Bioengineering
Volume 11
Issue 7
10.3390/bioengineering11070676
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Open AccessArticle
by Wolfgang A. Goetz SciProfiles Scilit Preprints.org Google Scholar Jiang Yao SciProfiles Scilit Preprints.org Google Scholar Michael Brener SciProfiles Scilit Preprints.org Google Scholar Rishi Puri SciProfiles Scilit Preprints.org Google Scholar Dr. Rishi Puri, MD, PhD, FRACP is an interventional cardiologist in the Section of Invasive & in the[...] Read more Martin Swaans SciProfiles Scilit Preprints.org Google Scholar Simon Schopka SciProfiles Scilit Preprints.org Google Scholar Sigrid Wiesner SciProfiles Scilit Preprints.org Google Scholar Marcus Creutzenberg SciProfiles Scilit Preprints.org Google Scholar Horst Sievert SciProfiles Scilit Preprints.org Google Scholar Ghassan S. Kassab SciProfiles Scilit Preprints.org Google Scholar Dr. Ghassan S. Kassab is Chairman of the Board and Institute Professor at the California Medical He[...] Read more
Wolfgang A. Goetz
, Jiang Yao, Michael BrenerRishi PuriMartin Swaans, Simon SchopkaSigrid WiesnerMarcus CreutzenbergHorst SievertGhassan S. Kassab
1
Cardiothoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany
2
Dassault Systémes, Johnston, RI 02919, USA
3
Division of Cardiology, Columbia University Irving Medical Center, New York, NY 10027, USA
4
Cleveland Clinic, Cleveland, OH 44195, USA
5
St. Antonius Ziekenhuis, 3435 Nieuwegein, The Netherlands
6
CardioVascular Center, 60389 Frankfurt, Germany
7
California Medical Innovations Institute, San Diego, CA 92121, USA
*
Author to whom correspondence should be addressed.
Bioengineering 2024, 11(7), 676; https://doi.org/10.3390/bioengineering11070676
Submission received: 13 May 2024 / Revised: 24 June 2024 / Accepted: 28 June 2024 / Published: 2 July 2024
(This article belongs to the Section Biomedical Engineering and Biomaterials)
Abstract
Left ventricular (LV) longitudinal function is mechanically coupled to the elasticity of the ascending aorta (AA). The pathophysiologic link between a stiff AA and reduced longitudinal strain and the subsequent deterioration in longitudinal LV systolic function is likely relevant in heart failure with preserved ejection fraction (HFpEF). The proposed therapeutic effect of freeing the LV apex and allowing for LV inverse longitudinal shortening was studied in silico utilizing the Living Left Heart Human Model (Dassault Systémes Simulia Corporation). LV function was evaluated in a model with (A) an elastic AA, (B) a stiff AA, and (C) a stiff AA with a free LV apex. The cardiac model simulation demonstrated that freeing the apex caused inverse LV longitudinal shortening that could abolish the deleterious mechanical effect of a stiff AA on LV function. A stiff AA and impairment of the LV longitudinal strain are common in patients with HFpEF. The hypothesis-generating model strongly suggests that freeing the apex and inverse longitudinal shortening may improve LV function in HFpEF patients with a stiff AA.
Keywords: finite element method; computational simulation; aortic stiffness; atrio-ventricular plane displacement; ventricular strain; ventricular function; left ventricular apex; inverse left ventricular shortening; HFpEF
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MDPI and ACS Style
Goetz, W.A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberg, M.; Sievert, H.; Kassab, G.S. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Bioengineering 2024, 11, 676. https://doi.org/10.3390/bioengineering11070676
AMA Style
Goetz WA, Yao J, Brener M, Puri R, Swaans M, Schopka S, Wiesner S, Creutzenberg M, Sievert H, Kassab GS. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Bioengineering. 2024; 11(7):676. https://doi.org/10.3390/bioengineering11070676
Chicago/Turabian Style
Goetz, Wolfgang A., Jiang Yao, Michael Brener, Rishi Puri, Martin Swaans, Simon Schopka, Sigrid Wiesner, Marcus Creutzenberg, Horst Sievert, and Ghassan S. Kassab. 2024. "Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF" Bioengineering 11, no. 7: 676. https://doi.org/10.3390/bioengineering11070676
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
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MDPI and ACS Style
Goetz, W.A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberg, M.; Sievert, H.; Kassab, G.S. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Bioengineering 2024, 11, 676. https://doi.org/10.3390/bioengineering11070676
AMA Style
Goetz WA, Yao J, Brener M, Puri R, Swaans M, Schopka S, Wiesner S, Creutzenberg M, Sievert H, Kassab GS. Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. Bioengineering. 2024; 11(7):676. https://doi.org/10.3390/bioengineering11070676
Chicago/Turabian Style
Goetz, Wolfgang A., Jiang Yao, Michael Brener, Rishi Puri, Martin Swaans, Simon Schopka, Sigrid Wiesner, Marcus Creutzenberg, Horst Sievert, and Ghassan S. Kassab. 2024. "Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF" Bioengineering 11, no. 7: 676. https://doi.org/10.3390/bioengineering11070676
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
Bioengineering, EISSN 2306-5354, Published by MDPI
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